Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.

  title={Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity.},
  author={Thomas A. Krenitsky and Joel V. Tuttle and George W Koszalka and I S Chen and L M Beacham and Janet L. Rideout and Gertrude Bell Elion},
  journal={The Journal of biological chemistry},
  volume={251 13},
Kinetic constants were determined for 34 nucleoside substrates of deoxycytidine kinase (EC from calf thymus. Substrate efficiency was assessed by the ratio of Vmax to Km. Inhibition constants were determined for 61 nonsubstrate nucleosides or nucleoside analogues. The enzyme was relatively specific for the pentose moiety of nucleoside substrates. beta-D-2'-Deoxyribonucleosides were more efficient substrates than the corresponding beta-D-arabinonucleosides. Unexpectedly, the L isomer… CONTINUE READING


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