Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.

@article{Qiao2001DeoxycholicAS,
  title={Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation.},
  author={Dianhua Qiao and Supriya V Gaitonde and Wenbo Qi and Jesse D. Martinez},
  journal={Carcinogenesis},
  year={2001},
  volume={22 6},
  pages={957-64}
}
Bile acids, principally deoxycholic acid (DCA), have been implicated in the promotion of colon tumorigenesis in both animals and humans. Increasing evidence suggests that bile acids may exert their tumor promoting activity by modulating intracellular signaling and altering gene expression. In this study we have investigated the effect of bile acids on the tumor suppressor p53 using the human colon tumor cell line HCT116, which retains the wild-type p53 gene and functional p53 signaling in… CONTINUE READING
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