Deoxycholic acid induces intracellular signaling through membrane perturbations.

  title={Deoxycholic acid induces intracellular signaling through membrane perturbations.},
  author={Samira Jean-Louis and Sandeep J Akare and Maha A. Ali and Eugene A. Mash and Emmanuelle Meuillet and Jesse D. Martinez},
  journal={The Journal of biological chemistry},
  volume={281 21},
Secondary bile acids have long been postulated to be tumor promoters in the colon; however, their mechanism of action remains unclear. In this study, we examined the actions of bile acids at the cell membrane and found that they can perturb membrane structure by alteration of membrane microdomains. Depletion of membrane cholesterol by treating with methyl-beta-cyclodextrin suppressed deoxycholic acid (DCA)-induced apoptosis, and staining for cholesterol with filipin showed that DCA caused a… CONTINUE READING