Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

@article{Qiao2001DeoxycholicA,
  title={Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.},
  author={Liang Qiao and Elaine J. Studer and Katie Leach and Robert P McKinstry and Surbhi Gupta and Roy Decker and Roshan Kukreja and Kristoffer Valerie and Prakash Nagarkatti and W El Deiry and Jeffery D Molkentin and Rupert Schmidt-Ullrich and Paul B Fisher and Steven Grant and Philip B. Hylemon and Paul Dent},
  journal={Molecular biology of the cell},
  year={2001},
  volume={12 9},
  pages={
          2629-45
        }
}
Previous studies have argued that enhanced activity of the epidermal growth factor receptor (EGFR) and the mitogen-activated protein kinase (MAPK) pathway can promote tumor cell survival in response to cytotoxic insults. In this study, we examined the impact of MAPK signaling on the survival of primary hepatocytes exposed to low concentrations of deoxycholic acid (DCA, 50 microM). Treatment of hepatocytes with DCA caused MAPK activation, which was dependent upon ligand independent activation of… CONTINUE READING

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