Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells

Abstract

The progression from Barrett's metaplasia to adenocarcinoma is associated with the acquirement of an apoptosis-resistant phenotype. The bile acid deoxycholate (DCA) has been proposed to play an important role in the development of esophageal adenocarcinoma, but the precise molecular mechanisms remain undefined. The aim of this study was to investigate DCA… (More)
DOI: 10.1186/1471-2407-9-190

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Cite this paper

@inproceedings{Looby2008DeoxycholateIC, title={Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells}, author={E. Joan Looby and M M Abdel-latif and Ver{\'o}nica Athi{\'e}-Morales and Shane P. Duggan and Aideen Long and Dermot Kelleher}, booktitle={BMC Cancer}, year={2008} }