DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.

@article{Boissy2005DeoxyArbutinAN,
  title={DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.},
  author={Raymond E. Boissy and Marty Visscher and Mitchell Anthony deLong},
  journal={Experimental dermatology},
  year={2005},
  volume={14 8},
  pages={601-8}
}
Modulation of melanogenesis in the melanocytes can be achieved using chemicals that share structural homologies with the substrate tyrosine and as thus competitively inhibit the catalytic function of tyrosinase. We have developed a new tyrosinase inhibitor, deoxyArbutin (dA), based on this premise. DeoxyArbutin demonstrates effective inhibition of mushroom tyrosinase in vitro with a Ki that is 10-fold lower that hydroquinone (HQ) and 350-fold lower than arbutin. In a hairless, pigmented guinea… CONTINUE READING

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