Dentin-derived BMP-2 and odontoblast differentiation.

@article{Casagrande2010DentinderivedBA,
  title={Dentin-derived BMP-2 and odontoblast differentiation.},
  author={L Casagrande and Fl{\'a}vio F Demarco and Zhaocheng Zhang and Fernando de Borba Ara{\'u}jo and Songtao Shi and Jacques Eduardo N{\"o}r},
  journal={Journal of dental research},
  year={2010},
  volume={89 6},
  pages={
          603-8
        }
}
It is known that stem cells from exfoliated deciduous teeth (SHED) can be induced to differentiate into odontoblasts. However, the nature of dentin-derived morphogenic signals required for dental pulp stem cell differentiation remains unclear. The hypothesis underlying this work is that dentin-derived Bone Morphogenetic Proteins (BMP) are necessary for the differentiation of SHED into odontoblasts. We observed that SHED express markers of odontoblastic differentiation (DSPP, DMP-1, MEPE) when… CONTINUE READING
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