Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.

@article{Miyashita1997DentatorubralPA,
  title={Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis.},
  author={Toshiyuki Miyashita and Yuko Okamura-Oho and Yasunori Mito and Shunpei Nagafuchi and Mitsuhiko Yamada},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 46},
  pages={29238-42}
}
Dentatorubral pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder. It is associated with an abnormal CAG repeat expansion resulting in formation of a protein with an elongated polyglutamine stretch. However, neither the physiological roles of the DRPLA gene product nor molecular mechanisms of its pathogenesis have yet been elucidated. Here we report that the DRPLA protein is cleaved at a site near the N terminus during apoptosis induced by VP-16, staurosporine, or… CONTINUE READING