Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures

@inproceedings{Toader2013DentateGN,
  title={Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures},
  author={Oana Daniela Toader and Nicola Forte and Marta Orlando and Enrico Ferrea and Andrea Raimondi and Pietro Baldelli and Fabio Benfenati and Lucian Medrihan},
  booktitle={Front. Cell. Neurosci.},
  year={2013}
}
Neuronal circuit disturbances that lead to hyperexcitability in the cortico-hippocampal network are one of the landmarks of temporal lobe epilepsy. The dentate gyrus (DG) network plays an important role in regulating the excitability of the entire hippocampus by filtering and integrating information received via the perforant path. Here, we investigated possible epileptogenic abnormalities in the function of the DG neuronal network in the Synapsin II (Syn II) knockout mouse (Syn II(-/-)), a… CONTINUE READING
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