Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

@article{McHugh2007DentateGN,
  title={Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network},
  author={Thomas J. McHugh and Matthew W. Jones and JenniferJ . Quinn and Nina Balthasar and Roberto Coppari and Joel K Elmquist and Bradford B. Lowell and Michael S. Fanselow and Matthew A. Wilson and Susumu Tonegawa},
  journal={Science},
  year={2007},
  volume={317},
  pages={94 - 99}
}
Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the… 

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