Dental plaque as a biofilm and a microbial community—Implications for treatment

@article{Marsh2015DentalPA,
  title={Dental plaque as a biofilm and a microbial community—Implications for treatment},
  author={Philip D. Marsh and D Head and Deirdre Ann Devine},
  journal={Journal of Oral Biosciences},
  year={2015},
  volume={57},
  pages={185-191}
}

Strategies to Combat Caries by Maintaining the Integrity of Biofilm and Homeostasis during the Rapid Phase of Supragingival Plaque Formation

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The present review summarizes the most important advances and future prospects for therapies based on the maintenance of biofilm integrity and homeostasis as a preventive measure of dysbiosis focused on these three key factors during the rapid phase of plaque formation.

Oral microbial biofilms: an update

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It is necessary for a dentist to consider dental caries as a result of a biological process to be targeted than treating the consequences of decay cavities, and the role of microbial biofilms in dental carie is discussed.

In Sickness and in Health—What Does the Oral Microbiome Mean to Us? An Ecological Perspective

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    Advances in dental research
  • 2018
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Evidence is provided to suggest that the regular provision of interventions that deliver small but relevant benefits, consistently over a prolonged period, can support the maintenance of a symbiotic oral microbiome.

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface.

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This model served to unravel the impact of swallowed bacteria on cells involved in the enterohepatic circulation and can be adapted to assess pathogen viability and subsequent inflammation-associated changes, colonization capacity of probiotic mixtures, and ultimately, potential bacterial impact on the presystemic circulation.

Oral Biofilm and Its Impact on Oral Health, Psychological and Social Interaction

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Generally, oral biofilm is an escalating public health, psychological, and social threat that is highly linked to the food the authors eat, microbes they harbor and general health status and the promising approaches to alleviate the problems are provided.

Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance

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An antibiotic-free strategy to disrupt the biofilm by engineered clustered carbon dot nanoparticles that function in the acidic environment of the biofilms is proposed that could effectively suppress the growth of S. mutans.

influence of fixed orthodontic retainer on oral microbiota

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Fixed retainer may increase cariogenic and periodontal pathogens and compromise oral health, between healthy individuals and patient wearing fixed orthodontic retainers.

Lipidomic profiling of non-mineralized dental plaque and biofilm by untargeted UHPLC-QTOF-MS/MS and SWATH acquisition

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It was discovered that most lipid classes were highly elevated in the in vitro biofilm samples, in particular diacylglycerols, phosphatidylglycersols, and phosphatodylethanolamines (PEs), and an overall shift from even-chain lipid species to odd-chain lipids was observed in the cultivated biofilms.

Effects of Antimicrobial Peptide GH12 on the Cariogenic Properties and Composition of a Cariogenic Multispecies Biofilm

TLDR
The results showed that GH12 was more effective in suppressing S. mutans than the other two species, with lower MIC and minimal bactericidal concentration values among diverse type strains and clinical isolated strains, and the use of GH12 might be of importance in preventing and controlling caries and other dental infections.

Effects of Arginine on Streptococcus mutans Growth, Virulence Gene Expression, and Stress Tolerance

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It is found that arginine negatively impacts the growth, the pathogenic potential, and the tolerance of environmental stresses in a way that is likely to compromise the ability of S. mutans to cause disease.
...

References

SHOWING 1-10 OF 57 REFERENCES

Oral Biofilm Architecture on Natural Teeth

TLDR
In vivo observations on oral biofilms provide a clear vision on biofilm architecture and the spatial distribution of predominant species and identified for the first time in vivo that Lactobacillus sp.

Contemporary perspective on plaque control

TLDR
Patients should be taught effective plaque control techniques that maintain dental biofilms at levels compatible with oral health so as to retain the beneficial properties of the resident microflora while reducing the risk of dental disease from excessive plaque accumulation.

Ecological Approaches to Oral Biofilms: Control without Killing

TLDR
Modelling studies support the concept that either reducing the frequency of acid challenge and/or the terminal pH, or by merely slowing bacterial growth, results in maintaining a community of beneficial bacteria under conditions that might otherwise lead to disease (control without killing).

Dental plaque: biological significance of a biofilm and community life-style.

  • P. Marsh
  • Biology, Medicine
    Journal of clinical periodontology
  • 2005
TLDR
Dental plaque displays properties that are typical of biofilms and microbial communities in general, a clinical consequence of which is a reduced susceptibility to antimicrobial agents as well as pathogenic synergism.

Controlling the oral biofilm with antimicrobials.

Are dental diseases examples of ecological catastrophes?

Dental diseases are among the most prevalent and costly diseases affecting industrialized societies, and yet are highly preventable. The microflora of dental plaque biofilms from diseased sites is

Caries Ecology Revisited: Microbial Dynamics and the Caries Process

TLDR
An extension of the caries ecological hypothesis is proposed to explain the relation between dynamic changes in the phenotypic/genotypic properties of plaque bacteria and the demineralization/remineralization balance of the Caries process.

Non-Lethal Control of the Cariogenic Potential of an Agent-Based Model for Dental Plaque

Dental caries or tooth decay is a prevalent global disease whose causative agent is the oral biofilm known as plaque. According to the ecological plaque hypothesis, this biofilm becomes pathogenic

Prospects of oral disease control in the future – an opinion

TLDR
It is argued that progress in the control of oral diseases will depend on a paradigm shift away from approaches that have proved successful in medicine for many diseases with a specific microbial aetiology, while antimicrobial agents delivered by oral care products may function effectively, even at sub-lethal concentrations.

Bacterial skin commensals and their role as host guardians.

TLDR
Bacterial factors and traits of these two key members of the skin microbiota are presented and the elucidation of their roles in health-promoting or disease-causing processes could lead to new prophylactic and therapeutic strategies against skin disorders and other S. epidermidis/P.
...