Dental enamel cells express functional SOCE channels

  title={Dental enamel cells express functional SOCE channels},
  author={Meerim K. Nurbaeva and Miriam Eckstein and Axel R. Concepcion and C. I. Edvard Smith and Sonal Srikanth and Michael L. Paine and Yousang Gwack and Michael J. Hubbard and Stefan Feske and Rodrigo S. Lacruz},
  booktitle={Scientific reports},
Dental enamel formation requires large quantities of Ca(2+) yet the mechanisms mediating Ca(2+) dynamics in enamel cells are unclear. Store-operated Ca(2+) entry (SOCE) channels are important Ca(2+) influx mechanisms in many cells. SOCE involves release of Ca(2+) from intracellular pools followed by Ca(2+) entry. The best-characterized SOCE channels are the Ca(2+) release-activated Ca(2+) (CRAC) channels. As patients with mutations in the CRAC channel genes STIM1 and ORAI1 show abnormal enamel… CONTINUE READING


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