Dental cells express factors that regulate bone resorption.

  title={Dental cells express factors that regulate bone resorption.},
  author={C. S. Sheela Rani and Mary Macdougall},
  journal={Molecular cell biology research communications : MCBRC},
  volume={3 3},
Odontoblasts and osteoblasts produce similar highly mineralized extracellular matrices. In bone, osteoblasts/stromal cells regulate osteoclast (ocl) formation and bone resorption by producing factors like osteoprotegerin (OPG), osteoclast differentiating factor (ODF/RANKL), and macrophage colony-stimulating factor (M-CSF) that interact with hematopoietic ocl precursor cells. Using odontoblast and pulp cell lines, we detected a constitutive expression of OPG, RANKL, and M-CSF mRNA in both cell… CONTINUE READING


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