Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies

@article{Griffiths1984DensityON,
  title={Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies},
  author={Gareth Griffiths and Graham Warren and Patrick Quinn and Odile Mathieu-Costello and Hans H Hoppeler},
  journal={The Journal of Cell Biology},
  year={1984},
  volume={98},
  pages={2133 - 2141}
}
As the spike proteins of Semliki Forest virus (SFV) pass from their site of synthesis in the endoplasmic reticulum (ER) to the cell surface, they must be concentrated and freed from endogenous proteins. To determine the magnitude of this sorting process we have measured the density of spike proteins in membranes of the intracellular transport pathway. In this first paper, using stereological procedures, we have estimated the surface areas of the ER, Golgi complex, and plasma membrane of… CONTINUE READING

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