Density of apamin-sensitive Ca(2+)-dependent K+ channels in bovine chromaffin cells: relevance to secretion.

@article{Lara1995DensityOA,
  title={Density of apamin-sensitive Ca(2+)-dependent K+ channels in bovine chromaffin cells: relevance to secretion.},
  author={Baldomero Lara and Pedro Zapater and Carmen Montiel and Mar{\'i}a Teresa de la Fuente and Rafael Mart{\'i}nez-Sierra and Juan J. Ballesta and Luis Gand{\'i}a and A. G. Garcı́a},
  journal={Biochemical pharmacology},
  year={1995},
  volume={49 10},
  pages={
          1459-68
        }
}
Role of K+ channels in adrenal catecholamine secretion in anesthetized dogs.
TLDR
The results suggest that KA channels may play an inhibitory role in the regulation of adrenal CA secretion in response to SNS and that SKCa channels mayplay the same role inThe secretion in Response to exogenously applied cholinergic agonists.
Role of K+ channels in adrenal catecholamine secretion in anesthetized dogs.
TLDR
The results suggest that KA channels may play an inhibitory role in the regulation of adrenal CA secretion in response to SNS and that SKCa channels mayplay the same role inThe secretion in Response to exogenously applied cholinergic agonists.
Chromaffin Cells of the Adrenal Medulla: Physiology, Pharmacology, and Disease.
TLDR
An updated account of well-established features of the molecular processes regulating CC function are provided, and a survey of the as-yet-unsolved but important questions relating to CC function and dysfunction are surveyed.
Generating a High Affinity Scorpion Toxin Receptor in KcsA-Kv1.3 Chimeric Potassium Channels*
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A structural model for the complex between KcsA-Kv1.3 chimeras and kaliotoxin is developed to aid future pharmacological studies of K+ channels and shows that a subregion of the S5-S6 linker may be an important determinant of the pharmacological profile of K- channels.
Recent advances in the biology of small conductance calcium-activated potassium channels
TLDR
The information gained from improved understanding of the molecular nature of SK channels is already helping to elucidate the molecular basis of drug interactions, as well as to further define the physiological function and tissue distribution of these channels.
Augmentation of catecholamine release elicited by an Eugenia punicifolia extract in chromaffin cells
TLDR
The effects of an E. punicifolia dichloromethane extract (EPEX) in a neuronal model of cholinergic neurotransmission, the bovine adrenal chromaffin cell are investigated to help to identify the active component responsible for augmenting exocytosis.
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TLDR
Results are compatible with the idea that muscarinic stimulation depolarizes the cat adrenal chromaffin cell through an unidentified mechanism and inhibition of Ca2+i‐dependent K+ channels enhances depolarization and firing of action potentials.
Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release.
TLDR
The ability of histamine and AII to sustain (or promote) Ca2+ entry appears to underlie their efficacy as secretagogues, and evidence linking agonist-dependent patterns of [Ca2+]i changes in single cells with agonists-dependent functional responses is provided.
Characterization and Ca2+ Requirement of Histamine‐Induced Catecholamine Secretion in Cultured Bovine Chromaffin Cells
TLDR
The results indicate that stimulation with histamine induces a continuous secretion via the H1 receptor, in addition to a transient and nonspecific secretion at higher doses.
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TLDR
Comparison of the rates of secretion measured duringdepolarization to those produced by Ca2+ dialysis or release from internal stores suggests that [Ca2+]i at secretory sites can exceed 10 microM during depolarization.
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TLDR
After abolition of the secretory response through 60 s periods of wash‐out with a 0 Ca(2+)‐EGTA‐ionomycin solution, followed by delayed 5 s methacholine pulses after Ca2+o reintroduction, the glands instantly recovered their normal muscarinic‐mediatedsecretory response.
Effects of quinine and apamin on the calcium‐dependent potassium permeability of mammalian hepatocytes and red cells.
TLDR
It was concluded that quinine and apamin are able to block either the Ca‐dependent K channels present in guinea‐pig and rabbit liver cell membranes or the mechanism that controls them, and the results suggest that Ca‐ dependent K channels or carriers are present in the membranes of liver cells of the guinea-p pig and rabbit, but are either lacking or inactive in rat liver.
Separate Binding and Functional Sites for ω co‐Conotoxin and Nitrendipine Suggest Two Types of Calcium Channels in Bovine Chromaffin Cells
TLDR
Results suggest that two different types of Ca2+ channels might be present in chromaffin cells, however, the molecular identity of ω‐conotoxin binding sites remains to be determined.
Effects of apamin, quinine and neuromuscular blockers on calcium‐activated potassium channels in guinea‐pig hepatocytes.
TLDR
The bee venom peptide, apamin, has been radiolabelled with 125I, the monoiodinated derivative purified, and its binding to intact guinea‐pig liver cells studied, showing a saturable binding component compatible with 1:1 binding to a single class of site and having an equilibrium dissociation constant (KL) of 390 pM.
Ca-dependent K channels with large unitary conductance in chromaffin cell membranes
TLDR
Patches of membranes containing functional, Ca-dependent K channels have been isolated from chromaffin cells and it is shown that application of low Ca concentrations to the inner side of the membrane affects the properties of the channels, while Ca ions are ineffective on the outer side ofThe membrane.
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