Density functional theory calculations in stereochemical determination of terpecurcumins J-W, cytotoxic terpene-conjugated curcuminoids from Curcuma longa L.

@article{Lin2013DensityFT,
  title={Density functional theory calculations in stereochemical determination of terpecurcumins J-W, cytotoxic terpene-conjugated curcuminoids from Curcuma longa L.},
  author={Xionghao Lin and Shuai Ji and Xue Qiao and Hongbo Hu and Ni Chen and Yinhui Dong and Yun Huang and Dean Guo and Pengfei Tu and Min Ye},
  journal={The Journal of organic chemistry},
  year={2013},
  volume={78 23},
  pages={
          11835-48
        }
}
Fourteen novel terpene-conjugated curcuminoids, terpecurcumins J-W (1-14), have been isolated from the rhizomes of Curcuma longa L. Among them, terpecurcumins J-Q and V represent four unprecedented skeletons featuring an unusual core of hydrobenzannulated[6,6]-spiroketal (1 and 2), bicyclo[2.2.2]octene (3-7), bicyclo[3.1.3]octene (8), and spiroepoxide (13), respectively. The structures of compounds 1-14 were elucidated by extensive spectroscopic analysis, and their absolute configurations were… CONTINUE READING
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