Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors.

@article{Holley1977DensitydependentRO,
  title={Density-dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors.},
  author={Robert W. Holley and R W Armour and J H Baldwin and Kevin Brown and Yi Chun Yeh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1977},
  volume={74 11},
  pages={5046-50}
}
BSC-1 cells grow slowly, to high cell density, in medium with 0.1% calf serum. An increase in the serum concentration increases both the growth rate of the cells and the final cell density. The serum can be replaced to some extent by epidermal growth factor (EGF). Initiation of DNA synthesis in BSC-1 cells that have spread into a "wound" in a crowded cell layer requires the addition of a trace of serum or EGF, if the cells have previously been deprived of serum. The binding of 125I-labeled EGF… CONTINUE READING

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