Density-dependent regulation of cell growth by contactinhibin and the contactinhibin receptor

Abstract

BACKGROUND The number of cells within mammalian tissues is maintained by growth-stimulating and growth-inhibiting mechanisms, with inhibitory signals being superimposed over growth stimuli. This is reflected, in the culture of normal adherent cells, by the phenomenon of density-dependent inhibition of growth: cells cease proliferation after becoming a… (More)
DOI: 10.1016/S0960-9822(95)00105-9

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