Density-dependent limitation of growth and the regulation of cell replication by changes in the triggering level of the cell cycle switch.

@article{Gilbert1977DensitydependentLO,
  title={Density-dependent limitation of growth and the regulation of cell replication by changes in the triggering level of the cell cycle switch.},
  author={D. A. Gilbert},
  journal={Bio Systems},
  year={1977},
  volume={9 4},
  pages={215-28}
}
If the initiation/suppression of cell replication results from the operation of an intracellular switch, then proliferation control can be expected to occur through the modulation of its threshold setting or sensitivity. Assuming the existence of a threshold and the uptake of regulators by an equilibrium process, one can explain various types of dependency of the maximum cell density on the initial level of the regulator (e.g., serum) in the medium. Moreover it becomes theoretically possible to… CONTINUE READING