Density-dependence of functional development in spiking cortical networks grown in vitro

@article{Ham2009DensitydependenceOF,
  title={Density-dependence of functional development in spiking cortical networks grown in vitro},
  author={Michael I. Ham and Vadas Gintautas and Michael A. Rodriguez and Ryan A. Bennett and Cara L. Santa Maria and Lu{\'i}s M. A. Bettencourt},
  journal={Biological Cybernetics},
  year={2009},
  volume={102},
  pages={71-80}
}
During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of neuronal interactions in vitro. Two types of cortical networks, namely, dense and sparse with 50,000 and 12,500 total cells, respectively, are studied. Activation graphs that represent pairwise neuronal interactions are constructed using a competitive first… 
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