Density changes in lactose tablets.

  title={Density changes in lactose tablets.},
  author={John A. Hersey and J. E. Rees and E T Cole},
  journal={Journal of pharmaceutical sciences},
  volume={62 12},
Fell and Newton (1) considered the density changes during compaction at two different speeds of several particle-size fractions of crystalline and spray-dried lactose. They referred to earlier work in which we (2) reported that application of the Heckel (3) treatment allowed an interpretation of the mechanism of consolidation. Our work showed that while lactose consolidated by particle rearrangement, particle-size reduction, and plastic deformation, sodium chloride consolidated by particle… CONTINUE READING