Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

@article{Novershtern2011DenselyIT,
  title={Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis},
  author={Noa Novershtern and Aravind Subramanian and Lee N Lawton and Raymond H. Mak and W. Nicholas Haining and Marie McConkey and Naomi Habib and Nir Yosef and Cindy Y. Chang and Tal Shay and Garrett M. Frampton and Adam C B Drake and Ilya B. Leskov and Bjorn Nilsson and Fred Preffer and David M. Dombkowski and John W. Evans and Ted Liefeld and John S. Smutko and Jianzhu Chen and Nir Friedman and Richard A. Young and Todd R. Golub and Aviv Regev and Benjamin L. Ebert},
  journal={Cell},
  year={2011},
  volume={144},
  pages={296-309}
}
Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry. We identified modules of highly coexpressed genes, some of which… CONTINUE READING

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