Dense shell glycodendrimers as potential nontoxic anti-amyloidogenic agents in Alzheimer's disease. Amyloid-dendrimer aggregates morphology and cell toxicity.

@article{Klementieva2011DenseSG,
  title={Dense shell glycodendrimers as potential nontoxic anti-amyloidogenic agents in Alzheimer's disease. Amyloid-dendrimer aggregates morphology and cell toxicity.},
  author={Oxana Klementieva and N{\'u}ria Benseny-Cases and Alejandro Gella and Dietmar Appelhans and Brigitte Voit and Josep Roca Cladera},
  journal={Biomacromolecules},
  year={2011},
  volume={12 11},
  pages={
          3903-9
        }
}
Dendrimers have been proved to interact with amyloids, although most of dendrimers assayed in amyloidogenic systems are toxic to cells. The development of glycodendrimers, poly(propyleneimine) (PPI) dendrimers decorated with maltose (Mal), represents the possibility of using dendrimers with a low intrinsic toxicity. In the present paper we show that fourth (PPI-G4-Mal) and fifth (PPI-G5-Mal) generation glycodendrimers have the capacity to interfere with Alzheimer's amyloid peptide Aβ(1-40… CONTINUE READING
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