Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility

@inproceedings{Takeuchi2017DenseGO,
  title={Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility},
  author={Masaki Takeuchi and Nobuhisa Mizuki and Akira Meguro and Michael J Ombrello and Yohei Kirino and Colleen L Satorius and Julie M. Le and Mary Blake and Burak Erer and Tatsukata Kawagoe and Duran Ustek and İlknur Tuğal-Tutkun and Emire Seyahi and Yilmaz Ozyazgan and In{\^e}s Sousa and Fereydoun Davatchi and V{\^a}nia Francisco and Farhad Shahram and Bahar Sadeghi Abdollahi and Abdolhadi Nadji and Niloofar Mojarad Shafiee and Fahmida Ghaderibarmi and Shigeaki Ohno and Atsuhisa Ueda and Yoshiaki I Ishigatsubo and Massimo Gadina and Sofia Almeida Oliveira and Ahmet G{\"u}l and Daniel L. Kastner and Elaine F. Remmers},
  booktitle={Nature Genetics},
  year={2017}
}
We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A–IL1B, IRF8, and CEBPB–PTPN1, with genome-wide significance (P < 5 × 10−8) by direct genotyping and ADO–EGR2 by imputation. We replicated the ADO–EGR2, IRF8, and CEBPB–PTPN1 loci by genotyping 969 Iranian cases and 826 controls. Imputed data in 608… CONTINUE READING