Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.

@article{Zahn2004DenseCV,
  title={Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.},
  author={Tobias R Zahn and Joseph K. Angleson and Margaret Macmorris and Erin Domke and John F Hutton and Cindi Schwartz and John C. Hutton},
  journal={Traffic},
  year={2004},
  volume={5 7},
  pages={544-59}
}
We have developed a model system in Caenorhabditis elegans to perform genetic and molecular analysis of peptidergic neurotransmission using green fluorescent protein (GFP)-tagged IDA-1. IDA-1 represents the nematode ortholog of the transmembrane proteins ICA512 and phogrin that are localized to dense core secretory vesicles (DCVs) of mammalian neuroendocrine tissues. IDA-1::GFP was expressed in a small subset of neurons and present in both axonal and dendritic extensions, where it was localized… CONTINUE READING

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