Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy.

@article{Rak2007DensecoreAD,
  title={Dense-core and diffuse Abeta plaques in TgCRND8 mice studied with synchrotron FTIR microspectroscopy.},
  author={M. Rak and Marc R Del Bigio and Sabine Kathrin Mai and David Westaway and Kathleen M. Gough},
  journal={Biopolymers},
  year={2007},
  volume={87 4},
  pages={207-17}
}
Plaques composed of the Abeta peptide are the main pathological feature of Alzheimer's disease. Dense-core plaques are fibrillar deposits of Abeta, showing all the classical properties of amyloid including beta-sheet secondary structure, while diffuse plaques are amorphous deposits. We studied both plaque types, using synchrotron infrared (IR) microspectroscopy, a technique that allows the chemical composition and average protein secondary structure to be investigated in situ. We examined… CONTINUE READING

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