Dense cells in sickle cell anemia: the effects of gene interaction.

  title={Dense cells in sickle cell anemia: the effects of gene interaction.},
  author={Mary E. Fabry and John Gregory Mears and Pratibha Patel and K E Schaefer-Rego and Lynn Carmichael and Gisela Mart{\'i}nez and Ronald L. Nagel},
  volume={64 5},
In an attempt to uncover potential genetic sources of the clinical diversity of sickle cell anemia, we have characterized homozygous SS patients in the following ways: percentage of dense red blood cells (% F4) as determined from Percoll-Stractan continuous density gradients, alpha gene deletion, average percentage of hemoglobin F (% HbF), hemoglobin in g/dL, age, and sex. We find that alpha 4 individuals have a higher % F4 (mean 24% +/- 15%) than alpha 3 individuals (mean 12% +/- 8%) (P less… CONTINUE READING
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