Dense cells in sickle cell anemia: the effects of gene interaction.

@article{Fabry1984DenseCI,
  title={Dense cells in sickle cell anemia: the effects of gene interaction.},
  author={Mary E. Fabry and John Gregory Mears and Pratibha Patel and K E Schaefer-Rego and Lynn Carmichael and Gisela Mart{\'i}nez and Ronald L. Nagel},
  journal={Blood},
  year={1984},
  volume={64 5},
  pages={1042-6}
}
In an attempt to uncover potential genetic sources of the clinical diversity of sickle cell anemia, we have characterized homozygous SS patients in the following ways: percentage of dense red blood cells (% F4) as determined from Percoll-Stractan continuous density gradients, alpha gene deletion, average percentage of hemoglobin F (% HbF), hemoglobin in g/dL, age, and sex. We find that alpha 4 individuals have a higher % F4 (mean 24% +/- 15%) than alpha 3 individuals (mean 12% +/- 8%) (P less… CONTINUE READING
36 Citations
25 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Red cell density and rate of potassium loss are affected by hemoglobin F levels in sickle cell anemia

  • ME Fabry, ID Buchanan, RL Nagel
  • Clin Res 32:551A,
  • 1984

Frequent association of alpha thalassemia with splenic sequestration crisis and splenomegaly in sickle cell (SS) subjects

  • JG Mears, M Schoenbrun, KE Schaefer, M Bestak, E Radel
  • Blood 60:47a,
  • 1982

Serjeant GR: The interaction of alpha-thalassemia and homozygous sickle-cell disease

  • BE Higgs DR. Aldridge, J Lamb, +6 authors BE Serjeant
  • N Engl J Med 306:1,441,
  • 1982

Similar Papers

Loading similar papers…