Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.

@article{Pepperl2000DenseBO,
  title={Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression.},
  author={S Pepperl and Jan M{\"u}nster and Michael Mach and Julie R. Harris and Bodo Plachter},
  journal={Journal of virology},
  year={2000},
  volume={74 13},
  pages={6132-46}
}
Infection of fibroblast cell cultures with human cytomegalovirus (HCMV) leads to the production of significant amounts of defective enveloped particles, termed dense bodies (DB). These noninfectious structures contain major antigenic determinants which are responsible for induction of both the humoral and the cellular immune response against HCMV. We tested the hypothesis that, by virtue of their unique antigenic and structural properties, DB could induce a significant immune response in the… CONTINUE READING

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