Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb

@article{Wanner2016DenseER,
  title={Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb},
  author={Adrian A. Wanner and Christel Genoud and Tafheem Masudi and L{\'e}a Siksou and Rainer W. Friedrich},
  journal={Nature Neuroscience},
  year={2016},
  volume={19},
  pages={816-825}
}
The dense reconstruction of neuronal circuits from volumetric electron microscopy (EM) data has the potential to uncover fundamental structure–function relationships in the brain. To address bottlenecks in the workflow of this emerging methodology, we developed a procedure for conductive sample embedding and a pipeline for neuron reconstruction. We reconstructed ∼98% of all neurons (>1,000) in the olfactory bulb of a zebrafish larva with high accuracy and annotated all synapses on subsets of… CONTINUE READING
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