Denosumab: mechanism of action and clinical outcomes

@inproceedings{Hanley2012DenosumabMO,
  title={Denosumab: mechanism of action and clinical outcomes},
  author={David Arthur Hanley and Jonathan D Adachi and Andrea Bell and Victoria Kumpuris Brown},
  booktitle={International journal of clinical practice},
  year={2012}
}
AIMS To describe the mechanisms of action of denosumab, a novel antiresorptive agent, contrasting it with other antiresorptive and anabolic osteoporosis treatments. METHODS Published papers related to the mechanism of action of approved osteoporosis treatments were sought through MEDLINE searches. FINDINGS Osteoporotic fractures carry a substantial burden of morbidity and mortality, but pharmacotherapy can prevent such fractures in high-risk individuals. Antiresorptive drugs (e.g… CONTINUE READING
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