Denosumab: A comprehensive review

  title={Denosumab: A comprehensive review},
  author={Prasad Narayanan},
  booktitle={South Asian journal of cancer},
The clinical sequelae from bone metastases, termed skeletal-related events (SREs), are among the most frequent and debilitating complications in patients with advanced cancer. Bone metastases are characterized by pathologically increased osteoclast activity, and accumulating evidence indicates that tumor cells interact within the bone to stimulate the receptor activator of nuclear factor kB (RANK)-RANK ligand (RANKL) pathway. RANKL is an essential mediator of osteoclast formation, function, and… CONTINUE READING