Denoising of LSFCM images with compensation for the photoblinking/photobleaching effects

Abstract

Fluorescence confocal microscopy images present a low signal to noise ratio and a time intensity decay due to the so called photoblinking and photobleaching effects. These effects, together with the Poisson multiplicative noise that corrupts the images, make long time biological observation processes very difficult. 
DOI: 10.1109/IEMBS.2010.5626159

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