Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody

@article{Halstead1977DengueVA,
  title={Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody},
  author={S A Halstead and EJ O’Rourke},
  journal={The Journal of Experimental Medicine},
  year={1977},
  volume={146},
  pages={201 - 217}
}
Cultured mononuclear peripheral blood leukocytes (PBL) from nonimmune human beings and monkeys are nonpermissive to dengue 2 virus (D2V) infection at multiplicities of infection of 0.001-0.1, but become permissive when non-neutralizing dengue antibody is added to medium. D2V infection occurred in PBL prepared from anti-coagulated but not from defibrinated plasma. Infection enhancement was produced by multiple lots of heterotypic anti-dengue raised in several mammalian species. Homotypic anti… CONTINUE READING
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