Dengue virus life cycle: viral and host factors modulating infectivity

  title={Dengue virus life cycle: viral and host factors modulating infectivity},
  author={Izabela A. Rodenhuis-Zybert and Jan C. Wilschut and Jolanda M. Smit},
  journal={Cellular and Molecular Life Sciences},
Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50–100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious… 
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  • A. Rothman
  • Medicine, Biology
    Annals of the New York Academy of Sciences
  • 2009
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