Dengue virus life cycle: viral and host factors modulating infectivity

@article{RodenhuisZybert2010DengueVL,
  title={Dengue virus life cycle: viral and host factors modulating infectivity},
  author={Izabela A. Rodenhuis-Zybert and Jan C. Wilschut and Jolanda M. Smit},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={67},
  pages={2773-2786}
}
Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50–100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious… 
The contribution of host cells to dengue virus infectivity
TLDR
Results showed clearly that both serotype and host cell modulated the ability of the virus to infect cells.
Dengue Virus Immunopathogenesis: Lessons Applicable to the Emergence of Zika Virus.
Host-Virus Interactions in Dengue Infection indicate Targets for Detection and Therapeutic Interventions
TLDR
The critical events causing vascular endothelial permeability, which underpins the manifestations in humans of d Dengue haemorrhagic fever and dengue shock syndrome, are emphasised.
Autoimmunity in dengue pathogenesis.
A Coupled Mathematical Model of the Intracellular Replication of Dengue Virus and the Host Cell Immune Response to Infection
TLDR
A detailed intracellular DV replication model is developed and it is found that host factors involved in replication complex formation and virus particle production are crucial for replication efficiency.
Immune response to dengue virus and prospects for a vaccine.
TLDR
Vaccines will need to provide long-term protection against each of the four DENV serotypes by inducing neutralizing antibodies, and live, attenuated and various nonliving virus vaccines are in development.
Dengue Fever: An Overview
TLDR
This chapter reviews the etiology, epidemiology, diagnosis, pathophysiology, transmissions, manifestations, diagnosis and treatment, treatment, and prevention of dengue.
Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target
TLDR
The pathogenic roles of MIF and the regulation of M IF secretion during DENV infection are reviewed and whether MIF is a potential therapeutic target againstDENV infection is also discussed.
Dengue virus-like particles: construction and application
TLDR
The present minireview summarized the assembly and maturation of DENVs, the strategies and effective factors for dengue VLP construction, and the application of DENV VLPs.
...
...

References

SHOWING 1-10 OF 217 REFERENCES
Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and Pathogenesis
Dengue virus (DENV) is a member of the Flavivirus genus of the Flaviviridae family of enveloped, positive-strand RNA viruses. The Flavivirus genus includes viruses transmitted by mosquitoes and
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
TLDR
Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T- cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
TLDR
The results suggest that the EIP of DENV-2 in its vector may be shorter that the previously reported and that the tracheal system may facilitate DENV -2 dissemination from the midgut.
Role of antibodies in controlling dengue virus infection.
Selection for Virulent Dengue Viruses Occurs in Humans and Mosquitoes
TLDR
Infection and growth experiments showed that dengue serotype 2 viruses causing d Dengue hemorrhagic fever epidemics (Southeast Asian genotype) can outcompete viruses that causedengue fever only (American genotype).
T Lymphocyte Responses to Heterologous Secondary Dengue Virus Infections
  • A. Rothman
  • Medicine, Biology
    Annals of the New York Academy of Sciences
  • 2009
TLDR
This work has been exploring the role of dengue virus–specific T lymphocytes in the immunopathogenesis of plasma leakage, and the reaction of heterologous viral serotype during a secondary infection to expand to high levels and produce a skewed cytokine profile.
Dengue Viruses and Mononuclear Phagocytes
TLDR
Clinical and experimental studies on humans and monkeys have provided data from which were developed new and provocative concepts of possible immunopathologic mechanisms resulting in vascular permeability and hemorrhage in dengue infection.
Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.
TLDR
Phylogenetic analyses suggest that these genotypes of dengue type 2 virus originated in Southeast Asia and that they displaced the native, American genotype in at least four countries, and vaccination and other control efforts should therefore be directed at decreasing the transmission of these "virulent" genotypes.
A structural perspective of the flavivirus life cycle
TLDR
The structural organization of these viruses and their associated structural proteins has provided insight into the molecular transitions that occur during the viral life cycle, such as assembly, budding, maturation and fusion.
Dengue: an update.
...
...