Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells.

  title={Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells.},
  author={Rajas V Warke and Kris Xhaja and Katherine J. Martin and Marcia F Fournier and Sunil K. Shaw and Nathaly Brizuela and N Blumenfeld De Bosch and David S. Lapointe and Francis A. Ennis and Alan L Rothman and Irene Bosch},
  journal={Journal of virology},
  volume={77 21},
Endothelial cells are permissive to dengue virus (DV) infection in vitro, although their importance as targets of DV infection in vivo remains a subject of debate. To analyze the virus-host interaction, we studied the effect of DV infection on gene expression in human umbilical vein endothelial cells (HUVECs) by using differential display reverse transcription-PCR (DD-RTPCR), quantitative RT-PCR, and Affymetrix oligonucleotide microarrays. DD identified eight differentially expressed cDNAs… CONTINUE READING
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