Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand.

@article{Matsuda2005DengueVA,
  title={Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand.},
  author={Takehiro Matsuda and Alex Almasan and Mariko Tomita and Kazumi Tamaki and Mika Saito and Masayuki Tadano and H. Yagita and Takao Ohta and Naoki Mori},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 4},
  pages={1055-65}
}
Although hepatic injury is reported in cases with dengue haemorrhagic fever and dengue shock syndrome, its mechanism remains poorly understood. Several findings suggest that dengue virus (DEN) induces apoptosis of hepatocytes in vivo. In this work, DEN type 2 (DEN-2) strain NGC was shown to induce apoptosis in the hepatic cell line HepG2, and infection of HepG2 cells was found to induce Apo2 ligand (Apo2L, also known as tumour necrosis factor-related apoptosis-inducing ligand or TRAIL… CONTINUE READING

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