Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells

@inproceedings{Filomatori2017DengueVG,
  title={Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells},
  author={Claudia V. Filomatori and Juan Manuel Carballeda and Sergio M Villordo and Sebastian Aguirre and Horacio M Pallar{\'e}s and Ana M Maestre and Irma S{\'a}nchez-Vargas and Carol D. Blair and Cintia Fabri and Mar{\'i}a Alejandra Morales and Ana Fern{\'a}ndez-Sesma and Andrea V. Gamarnik},
  booktitle={PLoS pathogens},
  year={2017}
}
The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important viral human pathogen transmitted by insects, evolved a mechanism to differentially regulate the production of viral non-coding RNAs in mosquitos and humans, with a significant impact on viral fitness in each host. Flavivirus infections accumulate non… CONTINUE READING