Dengue virus activates cGAS through the release of mitochondrial DNA

@inproceedings{Sun2017DengueVA,
  title={Dengue virus activates cGAS through the release of mitochondrial DNA},
  author={Bo Sun and Karin B. Sundstr{\"o}m and Jun Jie Chew and Pradeep Bist and Esther Shuyi Gan and Hwee Cheng Tan and Kenneth Choon Meng Goh and Tanu Chawla and Choon Kit Tang and Eng Eong Ooi},
  booktitle={Scientific Reports},
  year={2017}
}
Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially since RNA is not known to activate cGAS. Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), we show that infection creates an endogenous source of cytosolic DNA in infected… CONTINUE READING

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