Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination

@article{Beatty2015DengueVN,
  title={Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination},
  author={P. Robert Beatty and Henry Puerta-Guardo and Sarah S Killingbeck and Dustin R Glasner and Kaycie Hopkins and Ethan Harris},
  journal={Science Translational Medicine},
  year={2015},
  volume={7},
  pages={304ra141-304ra141}
}
The four dengue virus serotypes (DENV1 to DENV4) are mosquito-borne flaviviruses that cause up to ~100 million cases of dengue annually worldwide. Severe disease is thought to result from immunopathogenic processes involving serotype cross-reactive antibodies and T cells that together induce vasoactive cytokines, causing vascular leakage that leads to shock. However, no viral proteins have been directly implicated in triggering endothelial permeability, which results in vascular leakage. DENV… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 42 references

Evaluation of a DNA

D. Fan Zheng, N. Gao, +4 authors J. An
Virus Res . • 2014

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