• Published 2019

Dengue genetic divergence 1 generates within-serotype antigenic 2 variation , but serotypes dominate 3 evolutionary dynamics 4

@inproceedings{Bell2019DengueGD,
  title={Dengue genetic divergence 1 generates within-serotype antigenic 2 variation , but serotypes dominate 3 evolutionary dynamics 4},
  author={Sidney M. Bell and Leah C Katzelnick and Trevor Bedford},
  year={2019}
}
Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is 12 historically assumed to be antigenically uniform. However, recent analyses suggest that antigenic 13 heterogeneity may exist within each serotype, but its source, extent and impact remain unclear. 14 Here, we construct a sequence-based model to directly map antigenic change to underlying genetic 15 divergence. We identify 49 specific substitutions and four colinear substitution clusters that 16 robustly… CONTINUE READING

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