Dengue fever

  title={Dengue fever},
  author={Senanayake A M Kularatne},
  journal={BMJ : British Medical Journal},
This clinical review has been developed for The BMJ in collaboration with BMJ Best Practice, based on a regularly updated web/mobile topic that supports evidence based decision making at the point of care. To view the complete and current version, please refer to the dengue fever ( topic on the BMJ Best Practice website. 

Validation of Decision Groups in Patients with Dengue Fever: A Study during 2015 Outbreak in Taiwan.

This study showed that decision Group C has a good predictive value for 30-day mortality, and further studies including validation in other nations are warranted.

Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India

Patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India are recommend stratifying patients according to the WHO classification of d Dengue and avoiding the use of thrombocytopenia as a single marker of the severity of the illness.

Pattern and Outcome of Dengue Fever in a Pediatric Tertiary Hospital: A Retrospective Report

Fever, abdominal pain, bleeding episodes, and rash were common presentations, and Hematological, hepatological, neurological, and pleural complications were not uncommon, and the outcome of the disease was adequate and there were no mortalities.

Series of 10 dengue fever cases with unusual presentations and complications in Sri Lanka: a single centre experience in 2016

Dengue is an extremely challenging infection to treat in the globe today and unusual presentation and complications could be fatal, if not detected early where therapeutic window period is very short.

A case report of dengue hemorrhagic fever complicated with diabetic ketoacidosis in a child: challenges in clinical management

This case report might inspire paediatricians to anticipate the possibility of DKA in children with DHF and meticulous monitoring of glycaemic control as well as fluid management is required to reduce the potential risk for severe complications of both conditions.

Travel/Tropical Medicine and Pandemic Considerations for the Global Surgeon

Post Dengue Fatigue Syndrome (PDFS) among Dengue IgM-Antibody Positive Patients at Batticaloa Teaching Hospital, Sri Lanka

Post dengue fatigue syndrome comprises of a variety of symptoms complex ranging from fatigue, muscle weakness and variable neurological abnormalities which have been reported in various parts of the world.

Identification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited setting

Age 41–50 years, female gender, persistent vomiting, thrombocytopenia, and elevated transaminases were early predictors of CP in dengue fever, and Elevated transaminase was the strongest predictor of CP during early illness.

[Dengue outbreak in Buenos Aires, Argentina, 2016: Clinical and hematological features in children].

Clinical and hematological features in children with confirmed dengue infection and the most frequent clinical manifestations were fever, headache and retro-ocular pain and Laboratory abnormalities were leukopenia, thrombocytopenia and increased liver enzymes.


Serum albumin and C-reactive protein can be used as potential markers to predict severity of illness in dengue infection.



Atypical manifestations of dengue

This review compiles descriptions of atypical manifestations of dengue, such as d Dengue encephalitis, dengus myocarditis,dengue hepatitis and dengu cholecystitis.

Efficacy of Clinical Diagnosis of Dengue Fever in Paediatric Age Groups as Determined by WHO Case Definition 1997 in Thailand

The study brought out the fact that WHO case definition for DF has very high sensitivity but runs the risk of over-diagnosis to the extent of 36.62% and found that the combination of fever with positive tourniquet or leukopenia and one other clinical manifestation was the best (PPV=72.72%).

Corticosteroids in the treatment of dengue illness.

  • S. Rajapakse
  • Medicine
    Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2009

Can Doctors Make an Accurate Diagnosis of Dengue Infections at an Early Stage

For early, effective and rapid control of dengue outbreak, TT or leukopenia is a good indicator for initiating immediate control measures and about 26% of d Dengue cases that have no TT positive with leuk Openia will be missed.

Corticosteroids for dengue infection.

To compare treatment of dengue with and without use of corticosteroids or placebo in relation to preventing shock-related death and disease progression in children and adults, a review of eight studies enrolling 948 participants.

Effects of Short-Course Oral Corticosteroid Therapy in Early Dengue Infection in Vietnamese Patients: A Randomized, Placebo-Controlled Trial

  • D. TamT. Ngọc B. Wills
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2012
Use of oral prednisolone for 3 days during the early acute phase of dengue virus infection appears to be safe, but did not reduce the rate of development of shock or other recognized complications of

Cardiac complications of a dengue fever outbreak in Sri Lanka, 2005.

Early clinical and laboratory indicators of acute dengue illness.

Simple clinical and laboratory parameters are identified that help to identify children with DF or DHF, including plasma AST levels were higher in children who developed DHF than in those with DF.

Acute management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour.

  • N. T. NgoX. Cao J. Farrar
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2001
A randomized blinded comparison of 4 fluids for initial resuscitation of 230 Vietnamese children with dengue shock syndrome found no clear advantage to using any of the 4 fluids, but the longest recovery times occurred in the lactated Ringer's group.