Dengue Virus Type 2 Antagonizes IFN-α but Not IFN-γ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell1

@article{Ho2005DengueVT,
  title={Dengue Virus Type 2 Antagonizes IFN-$\alpha$ but Not IFN-$\gamma$ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell1},
  author={Ling-Jun Ho and Li-Feng Hung and Chun-Yi Weng and Wan‐Lin Wu and Ping-Jen Chou and Yi-Ling Lin and Deh Ming Chang and Tong-Yuan Tai and Jenn-Haung Lai},
  journal={The Journal of Immunology},
  year={2005},
  volume={174},
  pages={8163 - 8172}
}
The immunopathogenesis mechanism of dengue virus (DV) infection remains elusive. We previously showed that the target of DV in humans is dendritic cells (DCs), the primary sentinels of immune system. We also observed that despite the significant amount of IFN-α induced; DV particles remain massively produced from infected DCs. It suggests that DV may antagonize the antiviral effect of IFN-α. Recent work in animal studies demonstrated the differential critical roles of antiviral cytokines… 

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