Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins.

@article{Scaturro2015DengueVN,
  title={Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins.},
  author={Pietro Scaturro and Mirko Cortese and Laurent Chatel-Chaix and Wolfgang Fischl and Ralf Bartenschlager},
  journal={PLoS pathogens},
  year={2015},
  volume={11 11},
  pages={e1005277}
}
Non-structural protein 1 (NS1) is one of the most enigmatic proteins of the Dengue virus (DENV), playing distinct functions in immune evasion, pathogenesis and viral replication. The recently reported crystal structure of DENV NS1 revealed its peculiar three-dimensional fold; however, detailed information on NS1 function at different steps of the viral replication cycle is still missing. By using the recently reported crystal structure, as well as amino acid sequence conservation, as a guide… CONTINUE READING
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Structural basis of Flavivirus NS1 assembly and antibody recognition.

Proceedings of the National Academy of Sciences of the United States of America • 2014
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