Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease.

@article{Bibari2013DenervationOT,
  title={Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease.},
  author={Oiivier Bibari and Siak Kuan Lee and Tracey C. Dickson and Stan T Mitew and James Clement Vickers and Meng Inn Chuah},
  journal={Current Alzheimer research},
  year={2013},
  volume={10 7},
  pages={688-96}
}
The aggregation of beta-amyloid (Aβ) into plaques in the extracellular compartment of the brain is a pathological hallmark of Alzheimer' s disease (AD). Although the pathways for misprocessing of Aβ leading to plaque formation are not well understood, they may be related to synapse turnover and neuron activity. In this study, we have utilised transgenic… CONTINUE READING