Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease.

@article{Aicher2015DenervationOT,
  title={Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease.},
  author={Sue A. Aicher and Sam M. Hermes and Deborah M Hegarty},
  journal={Investigative ophthalmology & visual science},
  year={2015},
  volume={56 11},
  pages={6981-9}
}
PURPOSE Some dry eye disease (DED) patients have sensitized responses to corneal stimulation, while others experience hypoalgesia. Many patients have normal tear production, suggesting that reduced tears are not always the cause of DED sensory dysfunction. In this study, we show that disruption of lacrimal innervation can produce hypoalgesia without changing basal tear production. METHODS Injection of a saporin toxin conjugate into the extraorbital lacrimal gland of male Sprague-Dawley rats… CONTINUE READING