Denervation caused by tullidora (Karwinskia humboldtiana).

  title={Denervation caused by tullidora (Karwinskia humboldtiana).},
  author={E. Julio Mu{\~n}oz-Mart{\'i}nez and Jordi Cueva and Pedro Joseph-Nathan},
  journal={Neuropathology and applied neurobiology},
  volume={9 2},
Crude homogenate of the seed of the tullidora (Coyotillo, buckthorn; Karwinskia humboldtiana) fruit or a purified neurotoxin extracted from it was administered orally to male Wistar rats. Three to 5 weeks later, gait disturbances and progressive flaccid paralysis of the hindlimbs appeared in these animals which were then submitted to acute experiments. Single twitch and tetanic contractions of the soleus muscle were studied in the tullidora treated rats. The twitch tension elicited by direct… CONTINUE READING