Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome

@inproceedings{Liu2016DenervationInducedAO,
  title={Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome},
  author={Haiming M Liu and Deborah A Ferrington and Cory W Baumann and LaDora V Thompson},
  booktitle={PloS one},
  year={2016}
}
The standard 26S proteasome is responsible for the majority of myofibrillar protein degradation leading to muscle atrophy. The immunoproteasome is an inducible form of the proteasome. While its function has been linked to conditions of atrophy, its contribution to muscle proteolysis remains unclear. Therefore, the purpose of this study was to determine if the immunoproteasome plays a role in skeletal muscle atrophy induced by denervation. Adult male C57BL/6 wild type (WT) and immunoproteasome… CONTINUE READING
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