Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.

@article{TovarYRomo2012DendriticSI,
  title={Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.},
  author={Luis B Tovar-Y-Romo and Namandj{\'e} N Bumpus and Daniel J Pomerantz and Lindsay B. Avery and Ned Sacktor and Justin C. Mcarthur and Norman J Haughey},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2012},
  volume={343 3},
  pages={
          696-703
        }
}
Despite combination antiretroviral therapies (cARTs), a significant proportion of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND). Ongoing viral replication in the central nervous system (CNS) caused by poor brain penetration of cART may contribute to HAND. However, it has also been proposed that the toxic effects of long-term cART may contribute to HAND. A better understanding of the neurotoxic potential of cART is critically needed in light of the use of CNS… CONTINUE READING

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