Dendritic spikes as a mechanism for cooperative long-term potentiation

  title={Dendritic spikes as a mechanism for cooperative long-term potentiation},
  author={Nace L Golding and Nathan P. Staff and Nelson Spruston},
Strengthening of synaptic connections following coincident pre- and postsynaptic activity was proposed by Hebb as a cellular mechanism for learning. Contemporary models assume that multiple synapses must act cooperatively to induce the postsynaptic activity required for hebbian synaptic plasticity. One mechanism for the implementation of this cooperation is action potential firing, which begins in the axon, but which can influence synaptic potentiation following active backpropagation into… CONTINUE READING
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