Dendritic epidermal T cells regulate skin antimicrobial barrier function.

  title={Dendritic epidermal T cells regulate skin antimicrobial barrier function.},
  author={Amanda S MacLeod and Saskia Hemmers and Olivia Garijo and Marianne Chabod and Kerri A. Mowen and Deborah A. Witherden and Wendy L. Havran},
  journal={The Journal of clinical investigation},
  volume={123 10},
The epidermis, the outer layer of the skin, forms a physical and antimicrobial shield to protect the body from environmental threats. Skin injury severely compromises the epidermal barrier and requires immediate repair. Dendritic epidermal T cells (DETC) reside in the murine epidermis where they sense skin injury and serve as regulators and orchestrators of immune responses. Here, we determined that TCR stimulation and skin injury induces IL-17A production by a subset of DETC. This subset of IL… CONTINUE READING
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